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Home Medical Marijuana

Patients hopeful for France’s medical cannabis experiment

nickymay by nickymay
June 12, 2021
in Medical Marijuana
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Patients hopeful for France’s medical cannabis experiment
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Medical doctors are slowly enrolling sufferers in France’s first experiment with medical hashish, three months after it started. Many are desirous to entry the drug to handle a spread of issues, together with persistent ache, however participation within the experiment is onerous – and probabilities of success, for many, are slim.

“Sufferers are actually desirous to get these merchandise. They know they’re out there in different nations and a few of them have been overseas to get them,” says neurologist Didier Bouhassira.

He’s a ache specialist at one in all France’s largest ache centres at the Ambroise Paré hospital in Boulogne, west of Paris, and is concerned in an experiment that’s testing out the prescription and distribution of medical hashish in France.

Although guidelines are altering, and CBD, one of many elements of hashish, is changing into more and more out there in France, THC, the primary psychoactive ingredient of the plant, stays unlawful, and consuming marijuana is an offense.

Troublesome selections

“Many sufferers are asking for hashish. They’re impatient for this experiment,” says Bouhassira. “However sadly only a few are going to be concerned.”

The 2-year experiment will contain 3,000 folks – 700 of whom endure from persistent ache. Solely three or 4 of Bouhassira’s sufferers might be concerned, which suggests he has needed to make troublesome selections.

Take heed to a report on one in all Bouhassira’s first contributors within the hashish experiment, within the Spotlight on France podcast:

Spotlight on France, episode 56
Spotlight on France, episode 56 © RFI

To participate within the experiment, sufferers should endure from extreme, neuropathic ache that doesn’t reply to different medicine.

“Many neurological illnesses are related to very extreme neuropathic ache,” Bouhassira explains. “Even opioids don’t work very effectively in these sufferers. So we use antidepressants, or anticonvulsants, which often don’t have anything to do with ache.”

A number of dozen of his sufferers qualify for the experiment however the necessities are onerous sufficient that solely a handful will truly enroll.

“If you take part on this experimentation, you can not drive, in order that’s an exclusion standards,” he says, including that participation is just not straightforward, with month-to-month appointments and lots of paperwork.

“Once we clarify all of the constraints, lots of them decline, as a result of it’s too difficult.”

Fixed ache

Johanne Seneco was keen to participate. Bouhassira had her come from her dwelling in Amiens to enrol.

She arrives within the workplace together with her husband, strolling with a cane.

“I really feel like I’m on fireplace, I really feel burning from my head to my toes, continually,” she says, her face pinched behind a surgical masks.

Seneco has been seeing Bouhassira for ache administration since 2015, after a botched knee operation the yr earlier than severed nerves and left her with extreme ache in her leg that has since unfold throughout her complete physique, triggering a dysfunction referred to as complicated regional ache syndrome.

She is in fixed, extreme ache, 24 hours a day. She can’t transfer effectively on her personal and can’t work. She needed to depart her job as an assistant in a center college, and he or she spends most of her days in mattress propped up with pillows.

“I’ve misplaced every part,” she says, her eyes welling up. “The toughest factor is the influence it has had on my daughter. She is eighteen now, however for the final seven years she has not had a mom.”

Bouhassira has Seneco fill out kinds and questionnaires asking about her ache ranges and her way of thinking. She must fill these out at month-to-month physician’s visits all through the two-year experiment.

That is work she doesn’t thoughts doing, if it permits her to entry one thing that may assist ease her ache. She has tried many medicines, and coverings like hypnosis and acupuncture, none of which have labored. Some have made the ache worse.

Self-medication

Not like many who are suffering persistent ache, Seneco has by no means tried hashish.

“Medical doctors have instructed me to smoke a joint,” she says. “However I by no means dared as a result of I used to be frightened about what else could possibly be in it.”

A lot of Bouhassira’s different sufferers aren’t as hesitant.

“We talk about it brazenly with them, and we ask if they’ve tried smoking or taking it in different kinds,” he explains. “It’s vital for us to know.”

If hashish works, Bouhassira doesn’t discourage them from persevering with, although he warns of the chance of utilizing merchandise which might be unregulated.

“The issue is that there are not any controls on these merchandise that they purchase on-line or off the road,” he says.


Trial and error

After a half hour of paperwork, Bouhassira lastly presents Seneco with what she got here for: the prescription for sublingual drops of hashish oil, with an equal quantity of CBD and THC.

The prescription takes up a complete web page, as a result of she is to begin with a small quantity and improve each few days till she both feels her ache diminish, or has a adverse impact.

“You’ll improve very progressively, relying on the results,” Bouhassira explains. “There isn’t a mounted dose. We regulate for every affected person.”

Prescription in hand, Seneco then makes her means all the way down to the pharmacy within the hospitals’ basement, the place a pharmacist spends a half hour going over the prescription.

Pharmacists are key

The experiment is just not a drug trial however a take a look at of the logistics of prescribing and distributing hashish, and household docs and pharmacists are being skilled to do it.

“I used to be as a result of I’m involved about every part having to do with ache,” explains a pharmacist within the south-west who went by way of the coaching, however who didn’t wish to be recognized, as hashish remains to be a fragile topic in France. “I wish to facilitate an environment friendly therapy for ache.”

The one-day on-line course targeted on dosages.

“It was to assist us be comfy with what’s on the prescription,” she says, although she has but put it into observe, with few sufferers enrolled within the experiment, which has been slowed down by Covid.

“The position of a pharmacist is to provide the proper medication, with the proper dosage and the proper data to help them,” she continues. “That is about supporting folks.”

In the direction of legalisation 

This experiment is “slightly distinctive” for a medicine in France, says Nicolas Authier, a health care provider and pharmacologist, and president of the scientific committee on medicinal hashish.

Such an experiment is critical, due to the authorized standing of hashish, which continues to have sturdy opponents within the authorities, at the same time as a rising majority of French folks support its legalisation.

The experiment is a step in direction of pushing the problem ahead.

“It’s possible that it will likely be troublesome to say no on the finish,” says Authier. “When you begin the experiment, it is often to take the time to organise what comes subsequent, and barely to cease every part afterwards.”

Excessive expectations

Seneco leaves the hospital pharmacy with a paper bag containing a small bottle of hashish oil, made by the Israeli firm Panaxia. It’s sufficient for a month, till she returns for her subsequent appointment with the physician for a brand new prescription.

She is raring to get dwelling and begin the therapy.

“What I’m in search of is reduction, as a result of I’ve no extra life,” she says. “I don’t count on to get to zero ache. But when I can cut back it by half, that may be fantastic.”

“It’s not a magic bullet,” says Bouhassira, who warns sufferers that hashish could not work. “Often it gives partial reduction.”

Authier says hashish is not going to work on a lot of the sufferers enrolled within the experiment, and it’s unclear for whom it would work: “For now, worldwide analysis has not been capable of say which profile of affected person is most certainly to answer these medicines.”

However some can have a great response, with “a transparent enchancment of their high quality of life”.

“That’s already one thing. We can have performed our work as physician,” he says. 


Take heed to the story of Bouhassira assembly Seneco within the Spotlight on France podcast, episode 56.

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